Product Overview
SeroLigand™ Factor VIII Matrix
Peptide Ligand Affinity Matrix for Recombinant Factor VIII Purification
SeroLigand™ Factor VIII Matrix from Serox GmbH is a peptide ligand-based affinity chromatography resin specifically designed for the selective purification of recombinant Factor VIII (FVIII) molecules used in bioprocess and downstream purification applications.
The matrix utilizes a synthetic peptide ligand technology engineered to provide high selectivity, excellent recovery, and mild elution conditions for sensitive FVIII products. The resin is suitable for purification of full-length recombinant Factor VIII as well as B-domain deleted (BDD) FVIII variants.
The affinity matrix supports scalable purification workflows from laboratory process development to industrial manufacturing environments.
Key Features
- Selective binding of recombinant Factor VIII
- Synthetic peptide ligand technology
- Optimized for sensitive FVIII molecules
- Mild elution conditions to preserve activity
- Excellent impurity reduction
- High process scalability
- Animal-origin free production
- Compatible with standard chromatography systems
- Robust cleaning compatibility
Applications
- Recombinant Factor VIII purification
- Hemophilia A bioprocess development
- Downstream purification workflows
- Capture chromatography
- Biopharmaceutical manufacturing
- Pilot and industrial-scale purification
Product Specifications
| Parameter | Specification |
|---|---|
| Product Name | SeroLigand™ Factor VIII Matrix |
| Product Type | Peptide Ligand Affinity Matrix |
| Target Molecule | Recombinant Factor VIII (FVIII) |
| Supported Variants | Full-Length FVIII / BDD-FVIII |
| Ligand Technology | Synthetic Peptide Ligand |
| Matrix Type | Cross-linked agarose |
| Particle Size | ~65-75 µm |
| Form | Liquid suspension |
| Binding Mechanism | Affinity interaction |
| Dynamic Binding Capacity | Process dependent |
| Recommended Flow Rate | 50-200 cm/h |
| Operating Temperature | 2°C to 25°C |
| Storage Temperature | 2°C to 8°C |
| Storage Solution | 20% ethanol |
| Pressure Stability | Compatible with standard chromatography systems |
| Cleaning Compatibility | Acidic and mild caustic cleaning solutions |
| Animal-Origin Components | None |
| Intended Use | Industrial and research use only |
Inquiry
Request price, lead time, documentation and technical suitability for your intended application.